Osmolar regulation of endothelin signaling in rat renal medullary interstitial cells.
نویسندگان
چکیده
منابع مشابه
Osmolar regulation of endothelin signaling in rat renal medullary interstitial cells.
We tested the hypothesis that endothelin (ET) responsiveness in the renal medulla is modulated by ambient osmolarity. Cultured renal medullary interstitial cells (RMICs) were incubated from 3 to 24 h in isosmolar culture medium (300 mOsm/kg H2O) or media rendered hyperosmolar (600 mOsm/kg H2O) by the addition of urea. Under hyperosmolar conditions, the peak of ET-evoked Ca2+ transient was blunt...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1995
ISSN: 0021-9738
DOI: 10.1172/jci118019